Access to Soliris®

Physicians who care for patients with rare diseases need to be able to use innovative, safe and effective new therapies to treat their patients. Alexion is committed to the objective that every patient who can benefit from Soliris® (eculizumab) will have access to Soliris. Since Soliris has become available, the vast majority of patients for whom Soliris has been prescribed have gained access to the drug rapidly and efficiently.

As part of its commitment to the PNH community in the United States, Alexion offers the OneSource Treatment Support Program, a personalized service for patients and their health care providers. Each patient who enrolls in OneSource is assigned a specific Alexion Nurse Case Manager who supports the patient immediately and over time, providing a broad range of services from disease education to coordinating care between the physician's office and the insurer and assistance with searches for alternative payment or funding options.

All Alexion Nurse Case Managers are registered nurses who have extensive experience caring for patients and working in the health insurance industry. The OneSource Treatment Support Program has helped many patients with PNH understand their treatment options and make the most of their treatment plan. Patients and caregivers are encouraged to call whether they are being treated with Soliris or not.

For patients whose insurance is not adequate, our Alexion Nurse Case Managers can help to identify alternative coverage or funding. In addition, the National Organization for Rare Disorders (NORD) has established the PNH Fund to assist underinsured patients. Finally, our Alexion Nurse Case Managers will make referrals to the COMPLEMENT Foundation for patients who do not have insurance, access to insurance, or any other means for obtaining Soliris.

Alexion's commitment to access is for patients worldwide. The company works closely with physicians, patients, and health authorities around the world to facilitate access to Soliris.



IMPORTANT SAFETY INFORMATION

Soliris increases the risk of meningococcal infections. Meningococcal infection may become rapidly life-threatening or fatal if not recognized and treated early

Soliris® increases the risk of meningococcal infections

  • Vaccinate patients with a meningococcal vaccine at least 2 weeks prior to receiving the first dose of Soliris; revaccinate according to current medical guidelines for vaccine use
  • Monitor patients for early signs of meningococcal infections, evaluate immediately if infection is suspected, and treat with antibiotics if necessary

The effect of anticoagulant withdrawal during Soliris treatment has not been studied. Therefore, treatment with Soliris should not alter anticoagulant management.

Soliris is generally well tolerated. The most frequent adverse events observed in clinical studies were headache, a runny nose (nasopharyngitis), back pain, nausea, and tiredness (fatigue).